Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m(6)A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Xue, Miaoge, Zhao, Boxuan Simen, Zhang, Zijie, Lu, Mijia, Harder, Olivia, Chen, Phylip, Lu, Zhike, Li, Anzhong, Ma, Yuanmei, Xu, Yunsheng, Liang, Xueya, Zhou, Jiyong, Niewiesk, Stefan, Peeples, Mark E., He, Chuan, Li, Jianrong
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785563/
https://ncbi.nlm.nih.gov/pubmed/31597913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12504-y
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