A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in children of <5 years of age worldwide, infecting the majority of infants in their first year of life. Despite the widespread impact of this virus, no vaccine is currently available. For more than...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Jenkins, Tiffany, Wang, Rongzhang, Harder, Olivia, Xue, Miaoge, Chen, Phylip, Corry, Jacqueline, Walker, Christopher, Teng, Michael, Mejias, Asuncion, Ramilo, Octavio, Niewiesk, Stefan, Li, Jianrong, Peeples, Mark E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925107/
https://ncbi.nlm.nih.gov/pubmed/33177201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01568-20
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