Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m(6)A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of...

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Vydáno v:Nat Commun
Hlavní autoři: Xue, Miaoge, Zhao, Boxuan Simen, Zhang, Zijie, Lu, Mijia, Harder, Olivia, Chen, Phylip, Lu, Zhike, Li, Anzhong, Ma, Yuanmei, Xu, Yunsheng, Liang, Xueya, Zhou, Jiyong, Niewiesk, Stefan, Peeples, Mark E., He, Chuan, Li, Jianrong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785563/
https://ncbi.nlm.nih.gov/pubmed/31597913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12504-y
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