3-Substituted 1,5-Diaryl-1H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology

Cyclooxygenase-1 (COX-1) is a key enzyme in the biosynthesis of proinflammatory thromboxanes and prostaglandins and is found in glial and neuronal cells within brain. COX-1 expression is implicated in numerous neuroinflammatory states. We aim to find a direct-acting positron emission tomography (PET...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Singh, Prachi, Shrestha, Stal, Cortes-Salva, Michelle Y., Jenko, Kimberly J., Zoghbi, Sami S., Morse, Cheryl L., Innis, Robert B., Pike, Victor W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744613/
https://ncbi.nlm.nih.gov/pubmed/29678105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00102
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge