3-Substituted 1,5-Diaryl-1H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology

Cyclooxygenase-1 (COX-1) is a key enzyme in the biosynthesis of proinflammatory thromboxanes and prostaglandins and is found in glial and neuronal cells within brain. COX-1 expression is implicated in numerous neuroinflammatory states. We aim to find a direct-acting positron emission tomography (PET...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Singh, Prachi, Shrestha, Stal, Cortes-Salva, Michelle Y., Jenko, Kimberly J., Zoghbi, Sami S., Morse, Cheryl L., Innis, Robert B., Pike, Victor W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744613/
https://ncbi.nlm.nih.gov/pubmed/29678105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00102
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