The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development

MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). These translocations can occur as sole clonal driver mutations in infant leukemias, suggesting that fetal or neonatal hematopoietic progenitors may be exquisitely sensitive t...

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Bibliografski detalji
Izdano u:Blood Adv
Glavni autori: Okeyo-Owuor, Theresa, Li, Yanan, Patel, Riddhi M., Yang, Wei, Casey, Emily B., Cluster, Andrew S., Porter, Shaina N., Bryder, David, Magee, Jeffrey A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2019
Teme:
Myeloid Neoplasia
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693010/
https://ncbi.nlm.nih.gov/pubmed/31405949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000554
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