Single cell analysis of neonatal HSC ontogeny reveals gradual and uncoordinated transcriptional reprogramming that begins before birth

Fetal and adult hematopoietic stem cells (HSCs) have distinct proliferation rates, lineage biases, gene expression profiles and gene dependencies. While these differences are widely recognized, it is not clear how the transition from fetal to adult identity is coordinated. Here we show that murine H...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Li, Yanan, Kong, Wenjun, Yang, Wei, Patel, Riddhi M., Casey, Emily B., Okeyo-Owuor, Theresa, White, J. Michael, Porter, Shaina N., Morris, Samantha A., Magee, Jeffrey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655695/
https://ncbi.nlm.nih.gov/pubmed/32822583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.08.001
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