Single cell analysis of neonatal HSC ontogeny reveals gradual and uncoordinated transcriptional reprogramming that begins before birth

Fetal and adult hematopoietic stem cells (HSCs) have distinct proliferation rates, lineage biases, gene expression profiles and gene dependencies. While these differences are widely recognized, it is not clear how the transition from fetal to adult identity is coordinated. Here we show that murine H...

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Publicado no:Cell Stem Cell
Main Authors: Li, Yanan, Kong, Wenjun, Yang, Wei, Patel, Riddhi M., Casey, Emily B., Okeyo-Owuor, Theresa, White, J. Michael, Porter, Shaina N., Morris, Samantha A., Magee, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655695/
https://ncbi.nlm.nih.gov/pubmed/32822583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.08.001
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