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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
The myeloid tumor suppressor KMT2C is recurrently deleted in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly therapy-related MDS/AML (t-MDS/t-AML), as part of larger chromosome 7 deletions. Here, we show that KMT2C deletions convey a selective advantage to hematopoietic...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7951951/ https://ncbi.nlm.nih.gov/pubmed/33596429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108751 |
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