The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development

MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). These translocations can occur as sole clonal driver mutations in infant leukemias, suggesting that fetal or neonatal hematopoietic progenitors may be exquisitely sensitive t...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Okeyo-Owuor, Theresa, Li, Yanan, Patel, Riddhi M., Yang, Wei, Casey, Emily B., Cluster, Andrew S., Porter, Shaina N., Bryder, David, Magee, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693010/
https://ncbi.nlm.nih.gov/pubmed/31405949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000554
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