The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development

MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). These translocations can occur as sole clonal driver mutations in infant leukemias, suggesting that fetal or neonatal hematopoietic progenitors may be exquisitely sensitive t...

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Vydáno v:Blood Adv
Hlavní autoři: Okeyo-Owuor, Theresa, Li, Yanan, Patel, Riddhi M., Yang, Wei, Casey, Emily B., Cluster, Andrew S., Porter, Shaina N., Bryder, David, Magee, Jeffrey A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693010/
https://ncbi.nlm.nih.gov/pubmed/31405949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000554
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