The efficiency of murine MLL-ENL–driven leukemia initiation changes with age and peaks during neonatal development

MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML). These translocations can occur as sole clonal driver mutations in infant leukemias, suggesting that fetal or neonatal hematopoietic progenitors may be exquisitely sensitive t...

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Detalles Bibliográficos
Publicado en:Blood Adv
Main Authors: Okeyo-Owuor, Theresa, Li, Yanan, Patel, Riddhi M., Yang, Wei, Casey, Emily B., Cluster, Andrew S., Porter, Shaina N., Bryder, David, Magee, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2019
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693010/
https://ncbi.nlm.nih.gov/pubmed/31405949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000554
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