Exploitable metabolic dependencies in MLL-ENL–induced leukemia

Mixed-lineage leukemia (MLL) fusions are transcriptional activators that induce leukemia, with a dismal prognosis that mandates further elucidation of their transformation mechanism. In this study, knockdown of the direct MLL-ENL target gene polypyrimidine tract binding protein-1 (PTBP1) was rate li...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Garcia-Cuellar, Maria-Paz, Lawlor, Jennifer, Böttcher, Martin, Mougiakakos, Dimitrios, Metzler, Markus, Slany, Robert K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2020
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422118/
https://ncbi.nlm.nih.gov/pubmed/32766858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001710
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