Ryanodine receptor–bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in the cardiac type 2 ryanodine receptor (RyR2). Using a knockin (KI) mouse model (R2474S/+), we previously reported that a single point mutation within the RyR2 sensitizes the channel to agonists, prim...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Nakamura, Yoshihide, Yamamoto, Takeshi, Kobayashi, Shigeki, Tamitani, Masaki, Hamada, Yoriomi, Fukui, Go, Xu, Xiaojuan, Nishimura, Shigehiko, Kato, Takayoshi, Uchinoumi, Hitoshi, Oda, Tetsuro, Okuda, Shinichi, Yano, Masafumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629113/
https://ncbi.nlm.nih.gov/pubmed/31167968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126112
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi