Ryanodine receptor–bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in the cardiac type 2 ryanodine receptor (RyR2). Using a knockin (KI) mouse model (R2474S/+), we previously reported that a single point mutation within the RyR2 sensitizes the channel to agonists, prim...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Nakamura, Yoshihide, Yamamoto, Takeshi, Kobayashi, Shigeki, Tamitani, Masaki, Hamada, Yoriomi, Fukui, Go, Xu, Xiaojuan, Nishimura, Shigehiko, Kato, Takayoshi, Uchinoumi, Hitoshi, Oda, Tetsuro, Okuda, Shinichi, Yano, Masafumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629113/
https://ncbi.nlm.nih.gov/pubmed/31167968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126112
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