A model for the impact of FFPE section thickness on gene copy number measurement by FISH

Fluorescent in situ hybridization (FISH) assays to detect gene amplification such as HER2 or MET in tumors are used for prognosis evaluation and selection of targeted therapies. Although FISH guidelines recommended 4~6 μm FFPE sections, many laboratories use 2~3 μm sections, which is a common practi...

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Publicado en:Sci Rep
Autores principales: Yu, Jiyan, Wang, Qi, Xue, Pu, Zheng, Li, Mo, Juanfen, Chen, Liangye, Yin, Manxiang, Huang, Yueyan, Bao, Yi, Ding, Feng
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525178/
https://ncbi.nlm.nih.gov/pubmed/31101839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44015-7
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