A model for the impact of FFPE section thickness on gene copy number measurement by FISH

Fluorescent in situ hybridization (FISH) assays to detect gene amplification such as HER2 or MET in tumors are used for prognosis evaluation and selection of targeted therapies. Although FISH guidelines recommended 4~6 μm FFPE sections, many laboratories use 2~3 μm sections, which is a common practi...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Yu, Jiyan, Wang, Qi, Xue, Pu, Zheng, Li, Mo, Juanfen, Chen, Liangye, Yin, Manxiang, Huang, Yueyan, Bao, Yi, Ding, Feng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6525178/
https://ncbi.nlm.nih.gov/pubmed/31101839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44015-7
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