Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment

The opioid crisis is a significant public health issue with more than 115 people dying from opioid overdose per day in the United States. The aim of the present study was to characterize the in vitro and in vivo pharmacological effects of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-...

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Pubblicato in:ACS Chem Neurosci
Autori principali: Obeng, Samuel, Jali, Abdulmajeed, Zheng, Yi, Wang, Huiqun, Schwienteck, Kathryn L., Chen, Chongguang, Stevens, David L., Akbarali, Hamid I., Dewey, William L., Banks, Mathew L., Liu-Chen, Lee-Yuan, Selley, Dana E., Zhang, Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520168/
https://ncbi.nlm.nih.gov/pubmed/30758946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00038
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