Design, Syntheses, and Pharmacological Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan Analogues as Opioid Receptor Ligands

A series of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan (NAQ) analogues were synthesized and pharmacologically characterized to study their structure-activity relationship at the mu opioid receptor (MOR). The competition binding assay showed two-atom spa...

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Gepubliceerd in:Bioorg Med Chem
Hoofdauteurs: Yuan, Yunyun, Zaidi, Saheem A., Stevens, David L., Scoggins, Krista L., Mosier, Philip D., Kellogg, Glen E., Dewey, William L., Selley, Dana E., Zhang, Yan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380750/
https://ncbi.nlm.nih.gov/pubmed/25783191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.02.055
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