17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridylcarboxamido)morphinan (NAP) modulating the mu opioid receptor in a biased fashion

Mounting evidence has suggested that G protein-coupled receptors can be stabilized in multiple conformations in response to distinct ligands, which exert discrete functions through selective activation of various downstream signaling events. In accordance with this concept, we report biased signalin...

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Bibliographic Details
Published in:ACS Chem Neurosci
Main Authors: Zhang, Yan, Williams, Dwight A., Zaidi, Saheem A., Yuan, Yunyun, Braithwaite, Amanda, Bilsky, Edward J., Dewey, William L., Akbarali, Hamid I., Streicher, John M., Selley, Dana E.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111356/
https://ncbi.nlm.nih.gov/pubmed/26716358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00245
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