17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridylcarboxamido)morphinan (NAP) modulating the mu opioid receptor in a biased fashion

Mounting evidence has suggested that G protein-coupled receptors can be stabilized in multiple conformations in response to distinct ligands, which exert discrete functions through selective activation of various downstream signaling events. In accordance with this concept, we report biased signalin...

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Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Zhang, Yan, Williams, Dwight A., Zaidi, Saheem A., Yuan, Yunyun, Braithwaite, Amanda, Bilsky, Edward J., Dewey, William L., Akbarali, Hamid I., Streicher, John M., Selley, Dana E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111356/
https://ncbi.nlm.nih.gov/pubmed/26716358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00245
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