Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands

μ opioid receptor (MOR) agonists have been widely applied for treating moderate to severe pain. However, numerous adverse effects have been associated with their application, including opioid-induced constipation (OIC), respiratory depression, and addiction. On the basis of previous work in our labo...

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Dades bibliogràfiques
Publicat a:J Med Chem
Autors principals: Zheng, Yi, Obeng, Samuel, Wang, Huiqun, Jali, Abdulmajeed M., Peddibhotla, Bharath, Williams, Dwight A., Zou, Chuanchun, Stevens, David L., Dewey, William L., Akbarali, Hamid I., Selley, Dana E., Zhang, Yan
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467700/
https://ncbi.nlm.nih.gov/pubmed/30608693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01158
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