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In vitro and in vivo functional profile characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3-carboxamido)morphinan (NAQ) as a low efficacy mu opioid receptor modulator

Evidence has shown that downstream signaling by mu opioid receptor (MOR) agonists that recruit β-arrestin2 may lead to the development of tolerance. Also, it has been suggested that opioid receptor desensitization and cyclic AMP overshoot contributes to the development of tolerance and occurrence of...

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Опубликовано в: :Eur J Pharmacol
Главные авторы: Obeng, Samuel, Yuan, Yunyun, Jali, Abdulmajeed, Selley, Dana E., Zhang, Yan
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890425/
https://ncbi.nlm.nih.gov/pubmed/29530590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2018.03.013
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