Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4’-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective Mu Opioid Receptor Agents

Peripheral selective mu opioid receptor (MOR) antagonists could alleviate the symptoms of opioid-induced constipation (OIC) without compromising the analgesic effect of opioids. However, a variety of adverse effects were associated with them, partially due to their relatively low MOR selectivity. NA...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yuan, Yunyun, Elbegdorj, Orgil, Chen, Jianyang, Akubathini, Shashidhar K., Zhang, Feng, Stevens, David L., Beletskaya, Irina O., Scoggins, Krista L., Zhang, Zhenxian, Gerk, Phillip M., Selley, Dana E., Akbarali, Hamid I., Dewey, William L., Zhang, Yan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527108/
https://ncbi.nlm.nih.gov/pubmed/23116124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301247n
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak