Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4’-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective Mu Opioid Receptor Agents

Peripheral selective mu opioid receptor (MOR) antagonists could alleviate the symptoms of opioid-induced constipation (OIC) without compromising the analgesic effect of opioids. However, a variety of adverse effects were associated with them, partially due to their relatively low MOR selectivity. NA...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yuan, Yunyun, Elbegdorj, Orgil, Chen, Jianyang, Akubathini, Shashidhar K., Zhang, Feng, Stevens, David L., Beletskaya, Irina O., Scoggins, Krista L., Zhang, Zhenxian, Gerk, Phillip M., Selley, Dana E., Akbarali, Hamid I., Dewey, William L., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527108/
https://ncbi.nlm.nih.gov/pubmed/23116124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301247n
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados