17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridylcarboxamido)morphinan (NAP) modulating the mu opioid receptor in a biased fashion

Mounting evidence has suggested that G protein-coupled receptors can be stabilized in multiple conformations in response to distinct ligands, which exert discrete functions through selective activation of various downstream signaling events. In accordance with this concept, we report biased signalin...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Zhang, Yan, Williams, Dwight A., Zaidi, Saheem A., Yuan, Yunyun, Braithwaite, Amanda, Bilsky, Edward J., Dewey, William L., Akbarali, Hamid I., Streicher, John M., Selley, Dana E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111356/
https://ncbi.nlm.nih.gov/pubmed/26716358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00245
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