17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridylcarboxamido)morphinan (NAP) modulating the mu opioid receptor in a biased fashion

Mounting evidence has suggested that G protein-coupled receptors can be stabilized in multiple conformations in response to distinct ligands, which exert discrete functions through selective activation of various downstream signaling events. In accordance with this concept, we report biased signalin...

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Publicat a:ACS Chem Neurosci
Autors principals: Zhang, Yan, Williams, Dwight A., Zaidi, Saheem A., Yuan, Yunyun, Braithwaite, Amanda, Bilsky, Edward J., Dewey, William L., Akbarali, Hamid I., Streicher, John M., Selley, Dana E.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111356/
https://ncbi.nlm.nih.gov/pubmed/26716358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00245
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