Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

Human DNA polymerase ι (hPolι) promotes translesion synthesis by inserting nucleotides opposite highly distorting or noninstructional DNA lesions. Here, we provide evidence for the physical interaction of hPolι with proliferating cell nuclear antigen (PCNA), and show that PCNA, together with replica...

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Autores principales: Haracska, Lajos, Johnson, Robert E., Unk, Ildiko, Phillips, Barbara B., Hurwitz, Jerard, Prakash, Louise, Prakash, Satya
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC64669/
https://ncbi.nlm.nih.gov/pubmed/11724965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261560798
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