Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

Human DNA polymerase ι (hPolι) promotes translesion synthesis by inserting nucleotides opposite highly distorting or noninstructional DNA lesions. Here, we provide evidence for the physical interaction of hPolι with proliferating cell nuclear antigen (PCNA), and show that PCNA, together with replica...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Haracska, Lajos, Johnson, Robert E., Unk, Ildiko, Phillips, Barbara B., Hurwitz, Jerard, Prakash, Louise, Prakash, Satya
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11724965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.261560798
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