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Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

Human DNA polymerase ι (hPolι) promotes translesion synthesis by inserting nucleotides opposite highly distorting or noninstructional DNA lesions. Here, we provide evidence for the physical interaction of hPolι with proliferating cell nuclear antigen (PCNA), and show that PCNA, together with replica...

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Bibliographic Details
Main Authors: Haracska, Lajos, Johnson, Robert E., Unk, Ildiko, Phillips, Barbara B., Hurwitz, Jerard, Prakash, Louise, Prakash, Satya
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC64669/
https://ncbi.nlm.nih.gov/pubmed/11724965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261560798
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