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Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1
Inhibitors of Apoptosis Proteins (IAPs) are conserved E3‐ligases that ubiquitylate substrates to prevent apoptosis and activate the NF‐kB survival pathway, often deregulated in cancer. IAPs‐mediated regulation of NF‐kB signaling is based on the formation of protein complexes by their type‐I BIR doma...
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| 出版年: | ChemistryOpen |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6460348/ https://ncbi.nlm.nih.gov/pubmed/31011505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900059 |
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