Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment

Inhibitor of apoptosis (IAP) proteins are characterized by the presence of the conserved baculoviral IAP repeat (BIR) domain that is involved in protein-protein interactions. IAPs were initially thought to be mainly responsible for caspase inhibition, acting as negative regulators of apoptosis, but...

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Dettagli Bibliografici
Pubblicato in:Comput Struct Biotechnol J
Autori principali: Cossu, Federica, Milani, Mario, Mastrangelo, Eloise, Lecis, Daniele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Research Network of Computational and Structural Biotechnology 2019
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Review Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360406/
https://ncbi.nlm.nih.gov/pubmed/30766663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.01.009
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