Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP

We recently reported the systematic ligand-based rational design and synthesis of monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Expanded structure-activity relationship (SAR) studies around these peptidomimetics led to compounds with signifi...

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Autori principali: Ardecky, Robert J., Welsh, Kate, Finlay, Darren, Lee, Pooi San, González-López, Marcos, Reddy Ganji, Santhi, Ravanan, Palaniyandi, Mace, Peter D., Riedl, Stefan J., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772719/
https://ncbi.nlm.nih.gov/pubmed/23743278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.04.096
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