Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: Roles of XIAP and cIAPs

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) is a promising anti-cancer agent because it shows apoptosis-inducing activity in transformed, but not in normal cells. As with most anti-cancer agents, however, its clinical use is restricted by either inherent or acquired resistance by...

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Detalhes bibliográficos
Main Authors: Finlay, Darren, Vamos, Mitchell, González-López, Marcos, Ardecky, Robert J., Ganji, Santhi Reddy, Yuan, Hongbin, Su, Ying, Cooley, Trina R., Hauser, Curt T., Welsh, Kate, Reed, John C., Cosford, Nicholas D. P., Vuori, Kristiina
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947130/
https://ncbi.nlm.nih.gov/pubmed/24194568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0153
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