Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV(−) and HPV(+) Head and Neck Cancers To TNFα, TRAIL, and Radiation Therapy

PURPOSE: Human papilloma virus (HPV) negative head and neck squamous cell carcinomas (HNSCC) harbor frequent genomic amplification of Fas-Associated Death Domain (FADD), with or without concurrent amplification of Baculovirus inhibitor of apoptosis repeat containing (BIRC2/3) genes encoding cellular...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Xiao, Roy, An, Yi, Ye, Wenda, Derakhshan, Adeeb, Cheng, Hui, Yang, Xinping, Allen, Clint T., Chen, Zhong, Schmitt, Nicole C., Van Waes, Carter
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825532/
https://ncbi.nlm.nih.gov/pubmed/31266830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3802
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