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ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer

Inhibitor of apoptosis protein (IAP) antagonists have shown activity in preclinical models of head and neck squamous cell carcinoma (HNSCC), and work across several cancer types has demonstrated diverse immune stimulatory effects including enhancement of T cell, NK cell, and dendritic cell function....

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Ye, Wenda, Gunti, Sreenivasulu, Allen, Clint T., Hong, Youji, Clavijo, Paul E., Van Waes, Carter, Schmitt, Nicole C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959437/
https://ncbi.nlm.nih.gov/pubmed/32002309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1710398
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