Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer

Inhibitors of apoptosis proteins (IAPs) are intracellular proteins, with important roles in regulating cell death, inflammation, and immunity. Here, we examined the clinical and therapeutic relevance of IAPs in colorectal cancer. We found that elevated expression of cIAP1 and cIAP2 (but not XIAP) si...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Crawford, Nyree, Stott, Katie J., Sessler, Tamas, McCann, Christopher, McDaid, William, Lees, Andrea, Latimer, Cheryl, Fox, Jennifer P., Munck, Joanne M., Smyth, Tomoko, Shah, Alpesh, Martins, Vanessa, Lawler, Mark, Dunne, Philip D., Kerr, Emma M., McDade, Simon S., Coyle, Vicky M., Longley, Daniel B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2021
Assuntos:
Small Molecule Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611622/
https://ncbi.nlm.nih.gov/pubmed/34389694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-1050
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