Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer

Inhibitors of apoptosis proteins (IAPs) are intracellular proteins, with important roles in regulating cell death, inflammation, and immunity. Here, we examined the clinical and therapeutic relevance of IAPs in colorectal cancer. We found that elevated expression of cIAP1 and cIAP2 (but not XIAP) si...

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Publicat a:Mol Cancer Ther
Autors principals: Crawford, Nyree, Stott, Katie J., Sessler, Tamas, McCann, Christopher, McDaid, William, Lees, Andrea, Latimer, Cheryl, Fox, Jennifer P., Munck, Joanne M., Smyth, Tomoko, Shah, Alpesh, Martins, Vanessa, Lawler, Mark, Dunne, Philip D., Kerr, Emma M., McDade, Simon S., Coyle, Vicky M., Longley, Daniel B.
Format: Artigo
Idioma:Inglês
Publicat: American Association for Cancer Research 2021
Matèries:
Small Molecule Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611622/
https://ncbi.nlm.nih.gov/pubmed/34389694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-1050
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