Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

Expression of tumor necrosis factor-α (TNFα) in the serum of prostate cancer patients is associated with poorer outcome and progression to castrate-resistant (CRPC) disease. TNFα promotes the activity of NFκB, which regulates a number of anti-apoptotic and proinflammatory genes, including those enco...

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Pubblicato in:Cell Death Dis
Autori principali: McCann, Christopher, Crawford, Nyree, Majkut, Joanna, Holohan, Caitriona, Armstrong, Chris W. D., Maxwell, Pamela J., Ong, Chee Wee, LaBonte, Melissa J., McDade, Simon S., Waugh, David J., Longley, Daniel B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197283/
https://ncbi.nlm.nih.gov/pubmed/30349042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1125-5
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