The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cell-cycle arrest to apoptosis remains poorly understood. Using a combination of transcriptomics and functional genomics, we unexpectedly identified a nodal role for the cas...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lees, Andrea, McIntyre, Alexander J., Crawford, Nyree T., Falcone, Fiammetta, McCann, Christopher, Holohan, Caitriona, Quinn, Gerard P., Roberts, Jamie Z., Sessler, Tamas, Gallagher, Peter F., Gregg, Gemma M. A., McAllister, Katherine, McLaughlin, Kirsty M., Allen, Wendy L., Egan, Laurence J., Ryan, Aideen E., Labonte-Wilson, Melissa J., Dunne, Philip D., Wappett, Mark, Coyle, Vicky M., Johnston, Patrick G., Kerr, Emma M., Longley, Daniel B., McDade, Simon S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395556/
https://ncbi.nlm.nih.gov/pubmed/32661168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001520117
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