PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

PTEN loss is prognostic for patient relapse post-radiotherapy in prostate cancer (CaP). Infiltration of tumor-associated macrophages (TAMs) is associated with reduced disease-free survival following radical prostatectomy. However, the association between PTEN loss, TAM infiltration and radiotherapy...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Armstrong, Chris W.D., Maxwell, Pamela J., Ong, Chee Wee, Redmond, Kelly M., McCann, Christopher, Neisen, Jessica, Ward, George A., Chessari, Gianni, Johnson, Christopher, Crawford, Nyree T., LaBonte, Melissa J., Prise, Kevin M., Robson, Tracy, Salto-Tellez, Manuel, Longley, Daniel B., Waugh, David J.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4884961/
https://ncbi.nlm.nih.gov/pubmed/26799286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6955
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