Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer

Inhibitors of apoptosis proteins (IAPs) are intracellular proteins, with important roles in regulating cell death, inflammation, and immunity. Here, we examined the clinical and therapeutic relevance of IAPs in colorectal cancer. We found that elevated expression of cIAP1 and cIAP2 (but not XIAP) si...

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Bibliografske podrobnosti
izdano v:Mol Cancer Ther
Main Authors: Crawford, Nyree, Stott, Katie J., Sessler, Tamas, McCann, Christopher, McDaid, William, Lees, Andrea, Latimer, Cheryl, Fox, Jennifer P., Munck, Joanne M., Smyth, Tomoko, Shah, Alpesh, Martins, Vanessa, Lawler, Mark, Dunne, Philip D., Kerr, Emma M., McDade, Simon S., Coyle, Vicky M., Longley, Daniel B.
Format: Artigo
Jezik:Inglês
Izdano: American Association for Cancer Research 2021
Teme:
Small Molecule Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611622/
https://ncbi.nlm.nih.gov/pubmed/34389694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-1050
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