Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Unique Selectivity for ML-IAP

A series of novel, potent antagonists of the inhibitor of apoptosis proteins (IAPs) were synthesized in a highly convergent and rapid fashion (≤ 6 steps) using the Ugi four-component reaction as the key step, thus enabling rapid optimization of binding potency. These IAP antagonists compete with cas...

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Detalhes bibliográficos
Main Authors: Vamos, Mitchell, Welsh, Kate, Finlay, Darren, Lee, Pooi San, Mace, Peter D., Snipas, Scott J., Gonzalez, Monica L., Ganji, Santhi Reddy, Ardecky, Robert J., Riedl, Stefan J., Salvesen, Guy S., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D. P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953502/
https://ncbi.nlm.nih.gov/pubmed/23323685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3005512
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