Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (TNF) superfamily cytokines. Most IAPs are opposed endogenously by the second mitochondrial activator of caspases...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Welsh, Kate, Milutinovic, Snezana, Ardecky, Robert J., Gonzalez-Lopez, Marcos, Ganji, Santhi Reddy, Teriete, Peter, Finlay, Darren, Riedl, Stefan, Matsuzawa, Shu-ichi, Pinilla, Clemencia, Houghten, Richard, Vuori, Kristiina, Reed, John C., Cosford, Nicholas D. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019375/
https://ncbi.nlm.nih.gov/pubmed/27617834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161952
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