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Smac mimetics and TNFα: a dangerous liaison?
Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1 and cIAP2 are upregulated in many cancer cells. It has been thought that small molecule mimetics of Smac, an endogenous IAP antagonist, might potentiate apoptosis in cancer cells by promoting caspase activation. However, three recent papers...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3184251/ https://ncbi.nlm.nih.gov/pubmed/18022360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.10.042 |
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