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Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner

Second mitochondria-derived activator of caspase (Smac) is a mitochondrial protein released into the cytosol during apoptosis. Smac mimetics have recently been touted as a novel therapeutic to induce apoptosis in cancer cells. The ability of Smac mimetics to induce apoptosis in vitro has been shown...

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Detalhes bibliográficos
Main Authors: Probst, BL, Liu, L, Ramesh, V, Li, L, Sun, H, Minna, JD, Wang, L
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104849/
https://ncbi.nlm.nih.gov/pubmed/20431601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.44
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