Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer

Failure of chemotherapy in the treatment of pancreatic cancer is often due to resistance to therapy-induced apoptosis. A major mechanism for such resistance is the expression and activity of inhibitors of apoptosis proteins (IAPs). Smac is a mitochondrial protein that inhibits IAPs. We show that JP1...

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Bibliographic Details
Main Authors: Dineen, Sean P., Roland, Christina L., Greer, Rachel, Carbon, Juliet G., Toombs, Jason E., Gupta, Puja, Bardeesy, Nabeel, Sun, Haizhou, Williams, Noelle, Minna, John D., Brekken, Rolf A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848888/
https://ncbi.nlm.nih.gov/pubmed/20332237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3892
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