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Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner
Second mitochondria-derived activator of caspase (Smac) is a mitochondrial protein released into the cytosol during apoptosis. Smac mimetics have recently been touted as a novel therapeutic to induce apoptosis in cancer cells. The ability of Smac mimetics to induce apoptosis in vitro has been shown...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104849/ https://ncbi.nlm.nih.gov/pubmed/20431601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.44 |
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