Laddar...

Design and Synthesis of a Simplified Inhibitor for XIAP-BIR3 Domain

Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represent an attractive alternative to develop new c...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Pinacho Crisóstomo, Fernando R., Feng, Yongmei, Zhu, Xuejun, Welsh, Kate, An, Jing, Reed, John C., Huang, Ziwei
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807767/
https://ncbi.nlm.nih.gov/pubmed/19819692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.09.058
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!