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Design and Synthesis of a Simplified Inhibitor for XIAP-BIR3 Domain
Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represent an attractive alternative to develop new c...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3807767/ https://ncbi.nlm.nih.gov/pubmed/19819692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.09.058 |
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