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Recognition of Smac-mimetic compounds by the BIR domain of cIAP1
Inhibitor of apoptosis proteins (IAPs) are negative regulators of apoptosis. As IAPs are overexpressed in many tumors, where they confer chemoresistance, small molecules inactivating IAPs have been proposed as anticancer agents. Accordingly, a number of IAP-binding pro-apoptotic compounds that mimic...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009409/ https://ncbi.nlm.nih.gov/pubmed/20954235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.523 |
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