Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

Inhibitor of apoptosis proteins (IAPs) are negative regulators of apoptosis. As IAPs are overexpressed in many tumors, where they confer chemoresistance, small molecules inactivating IAPs have been proposed as anticancer agents. Accordingly, a number of IAP-binding pro-apoptotic compounds that mimic...

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Detalhes bibliográficos
Main Authors: Cossu, Federica, Malvezzi, Francesca, Canevari, Giulia, Mastrangelo, Eloise, Lecis, Daniele, Delia, Domenico, Seneci, Pierfausto, Scolastico, Carlo, Bolognesi, Martino, Milani, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009409/
https://ncbi.nlm.nih.gov/pubmed/20954235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.523
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