Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

Inhibitor of apoptosis proteins (IAPs) are negative regulators of apoptosis. As IAPs are overexpressed in many tumors, where they confer chemoresistance, small molecules inactivating IAPs have been proposed as anticancer agents. Accordingly, a number of IAP-binding pro-apoptotic compounds that mimic...

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Détails bibliographiques
Auteurs principaux: Cossu, Federica, Malvezzi, Francesca, Canevari, Giulia, Mastrangelo, Eloise, Lecis, Daniele, Delia, Domenico, Seneci, Pierfausto, Scolastico, Carlo, Bolognesi, Martino, Milani, Mario
Format: Artigo
Langue:Inglês
Publié: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009409/
https://ncbi.nlm.nih.gov/pubmed/20954235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.523
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