The Activator of Apoptosis Smac-DIABLO Acts as a Tetramer in Solution

Smac-DIABLO in its mature form (20.8 kDa) binds to baculoviral IAP repeat (BIR) domains of inhibitor of apoptosis proteins (IAPs) releasing their inhibitory effects on caspases, thus promoting cell death. Despite its apparent molecular mass (∼100 kDa), Smac-DIABLO was held to be a dimer in solution,...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Mastrangelo, Eloise, Vachette, Patrice, Cossu, Federica, Malvezzi, Francesca, Bolognesi, Martino, Milani, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317547/
https://ncbi.nlm.nih.gov/pubmed/25650938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.11.3471
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