Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Genetic alterations enhancing cell survival and suppressing apoptosis are hallmarks of cancer that significantly reduce the efficacy of chemotherapy or radiotherapy. The Inhibitor of Apoptosis Protein (IAP) family hosts conserved proteins in the apoptotic pathway whose over-expression, frequently fo...

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Bibliografiske detaljer
Main Authors: Cossu, Federica, Milani, Mario, Vachette, Patrice, Malvezzi, Francesca, Grassi, Serena, Lecis, Daniele, Delia, Domenico, Drago, Carmelo, Seneci, Pierfausto, Bolognesi, Martino, Mastrangelo, Eloise
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499469/
https://ncbi.nlm.nih.gov/pubmed/23166698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049527
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