Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic

Genetic alterations enhancing cell survival and suppressing apoptosis are hallmarks of cancer that significantly reduce the efficacy of chemotherapy or radiotherapy. The Inhibitor of Apoptosis Protein (IAP) family hosts conserved proteins in the apoptotic pathway whose over-expression, frequently fo...

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Hlavní autoři: Cossu, Federica, Milani, Mario, Vachette, Patrice, Malvezzi, Francesca, Grassi, Serena, Lecis, Daniele, Delia, Domenico, Drago, Carmelo, Seneci, Pierfausto, Bolognesi, Martino, Mastrangelo, Eloise
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499469/
https://ncbi.nlm.nih.gov/pubmed/23166698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049527
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