Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

BACKGROUND: XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by se...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lecis, D, Drago, C, Manzoni, L, Seneci, P, Scolastico, C, Mastrangelo, E, Bolognesi, M, Anichini, A, Kashkar, H, Walczak, H, Delia, D
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883696/
https://ncbi.nlm.nih.gov/pubmed/20461078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605687
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires