Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

BACKGROUND: XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by se...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lecis, D, Drago, C, Manzoni, L, Seneci, P, Scolastico, C, Mastrangelo, E, Bolognesi, M, Anichini, A, Kashkar, H, Walczak, H, Delia, D
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2010
Subjects:	Translational Therapeutics
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2883696/ https://ncbi.nlm.nih.gov/pubmed/20461078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605687
Tags:	Add Tag No Tags, Be the first to tag this record!

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

Similar Items