Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

BACKGROUND: XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by se...

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Detalhes bibliográficos
Main Authors: Lecis, D, Drago, C, Manzoni, L, Seneci, P, Scolastico, C, Mastrangelo, E, Bolognesi, M, Anichini, A, Kashkar, H, Walczak, H, Delia, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883696/
https://ncbi.nlm.nih.gov/pubmed/20461078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605687
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