EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells

TRAIL is a death receptor ligand that induces cell death preferentially in tumor cells. Recombinant soluble TRAIL, however, performs poorly as an anti-cancer therapeutic because oligomerization is required for potent biological activity. We previously generated a diabody format of tumor-targeted TRA...

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Detalhes bibliográficos
Main Authors: Möller, Yvonne, Siegemund, Martin, Beyes, Sven, Herr, Ricarda, Lecis, Daniele, Delia, Domenico, Kontermann, Roland, Brummer, Tilman, Pfizenmaier, Klaus, Olayioye, Monilola A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157814/
https://ncbi.nlm.nih.gov/pubmed/25198428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107165
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