Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

BACKGROUND: XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by se...

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Main Authors: Lecis, D, Drago, C, Manzoni, L, Seneci, P, Scolastico, C, Mastrangelo, E, Bolognesi, M, Anichini, A, Kashkar, H, Walczak, H, Delia, D
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883696/
https://ncbi.nlm.nih.gov/pubmed/20461078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605687
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